mProX™ Human PAK4 Stable Cell Line

[CAT#: S01YF-1023-PY43]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX418	Magic™ Human PAK4 in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;HeLa

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Endometrial Cancer

Gene ID

Human:10298

UniProt ID

Human:O96013

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

PAK4 inhibitors have shown promise in various applications related to cancer treatment. In one study, 4-(3-1H-indazolyl)amino quinazoline derivatives were synthesized as PAK4 inhibitors and exhibited potent inhibitory activity against PAK4. The compound 27e showed the strongest antiproliferative activity against A549 cells and induced apoptosis and cell cycle arrest. Additionally, PAK4 inhibition has been shown to potentiate the activity of Gemcitabine in pancreatic ductal adenocarcinoma (PDAC) cells by inhibiting key signaling pathways. Furthermore, PAK4 silencing, in combination with immunogenic phototherapy in engineered extracellular vesicles (EVs), has demonstrated synergistic antitumor effects. Lastly, the combination of PAK4 inhibitors with KRASG12C inhibitors has enhanced antitumor activity and survival in preclinical models of KRASG12C mutant pancreatic and lung cancers. Overall, PAK4 inhibitors show promise as potential targets for the development of novel anticancer therapies.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Alex Jones (Verified Customer)

How does PAK4 influence colorectal cancer progression? Sep 30 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

PAK4 promotes colorectal cancer progression by phosphorylating and activating the β-catenin/MEK-ERK signaling pathway. Sep 30 2022

chat Taylor Brown (Verified Customer)

Can PAK4 inhibitors alleviate hepatic ischemia-reperfusion injury? Apr 07 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

Yes, PAK4 inhibitors like SPA7012 have shown effectiveness in alleviating ischemia-reperfusion-induced liver damage by stabilizing Nrf2. Apr 07 2021

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