NOD2
This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
| Full Name | Nucleotide binding oligomerization domain containing 2 |
| Gene ID | Human: 64127 Mouse: 257632 Rat: 291912 Monkey: 695542 |
| UniProt ID | Human: Q9HC29 Mouse: Q8K3Z0 Rat: D4A5W3 Monkey: G7NPA3 |
| Alternative Names | CD; ACUG; BLAU; IBD1; YAOS; BLAUS; NLRC2; NOD2B; CARD15; CLR16.3; PSORAS1; nucleotide-binding oligomerization domain-containing protein 2; NLR family, CARD domain containing 2; NOD-like receptor C2; caspase recruitment domain family, member 15; caspase recruitment domain protein 15; caspase recruitment domain-containing protein 15; inflammatory bowel disease protein 1; nucleotide-binding oligomerization domain 2; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2 |
Product List
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Magic™ Human NOD2 HEK293 Cell Line with SEAP Reporter
[CAT#: S01YF-0123-KX382]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: NOD2 Target Family: Others Target Protein Species: Human Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
Magic™ Mouse NOD2 HEK293 Cell Line
[CAT#: S01YF-0123-KX439]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: NOD2 Target Family: Others Target Protein Species: Mouse Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
Magic™ Mouse NOD2 HEK293 Cell Line with SEAP Reporter
[CAT#: S01YF-0123-KX383]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: NOD2 Target Family: Others Target Protein Species: Mouse Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
mProX™ Human NOD2 Stable Cell Line
[CAT#: S01YF-1023-PY298]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Other Targets Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;ATDC-5
Magic™ Human NOD2 HEK293 Cell Line
[CAT#: S01YF-0123-KX438]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: NOD2 Target Family: Others Target Protein Species: Human Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
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