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MST1R

This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.

Full Name macrophage stimulating 1 receptor
Gene ID Human: 4486 Mouse: 19882 Rat: 300999 Monkey: 704437
UniProt ID Human: Q04912 Mouse: Q62190 Rat: D3ZYM4
Alternative Names RON; SEA; PTK8; CD136; NPCA3; CDw136; p185-Ron;macrophage-stimulating protein receptor;MSP receptor;PTK8 protein tyrosine kinase 8;S13 avian erythroblastosis oncogene homolog;S13 erythroblastosis oncogene homolog;c-met-related tyrosine kinase

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Product Category:
Membrane Protein Stable Cell Lines
Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;TC71;TC32;Rh30 Assay Types: Biological assays
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