mProX™ Human MST1R Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Published Data
Fig.1 Sensitization of sarcoma cells to BMS-536924 was achieved through the knockdown of MST1R.
Cell death response was assessed in cells transfected with siMST1R or siCTRL 48 hours prior and subsequently treated with BMS-536924 for 48 hours. Analysis of cell death was conducted through EthD-1 uptake, and results were depicted relative to the control group without BMS-536924 treatment, considering the impact of siRNAs independently and the direct correlation between EthD-1 fluorescence and the remaining cell numbers at each dosage. The data were presented as mean values (n = 3) with standard deviation bars.
Ref: Potratz, Jenny C., et al. "Synthetic lethality screens reveal RPS6 and MST1R as modifiers of insulin-like growth factor-1 receptor inhibitor activity in childhood sarcomas." Cancer research 70.21 (2010): 8770-8781.
Pubmed: 20959493
DOI: 10.1158/0008-5472.CAN-10-1093
Research Highlights
Shapiro, Dillon. et al. "Evolutionary Action-Machine Learning Model Identifies Candidate Genes Associated With Early-Onset Coronary Artery Disease." Journal of the American Heart Association, 2023.
In this study, the researchers aimed to investigate additional genetic factors contributing to coronary artery disease by utilizing machine learning techniques on evolutionary data from the Myocardial Infarction Genetics Consortium. By applying ensemble-based supervised learning, they identified 79 significant gene associations with coronary artery disease and found them to be linked to known risk loci and enriched in cardiovascular processes. Their results also revealed novel genes, including TXK, that may have a significant role in the development of coronary artery disease. These findings demonstrate the potential of machine learning in identifying complex genetic influences on disease.
Shapiro, Dillon. et al. "Evolutionary Action-Machine Learning Model Identifies Candidate Genes Associated With Early-Onset Coronary Artery Disease." Journal of the American Heart Association, 2023.
Pubmed:
37642027
DOI:
10.1161/JAHA.122.029103
Purwar, Roli. et al. "Novel mutations in a second primary gastric cancer in a patient treated for primary colon cancer." World journal of surgical oncology, 2023.
A 60-year-old male, previously treated for colon cancer, presented with abdominal pain and melena. He was diagnosed with a new primary stomach adenocarcinoma, distinct from his earlier colon cancer, and underwent treatment including CapOx with Bevacizumab, leading to gastric outlet obstruction. Subsequent total gastrectomy revealed advanced stage cancer. Novel mutations in KMT2A, LTK, and MST1R genes were identified, suggesting a unique genetic profile potentially influencing gastric cancer through miRNA modulation. This case underscores the need for further research into these specific genetic factors in gastric carcinogenesis.
Purwar, Roli. et al. "Novel mutations in a second primary gastric cancer in a patient treated for primary colon cancer." World journal of surgical oncology, 2023.
Pubmed:
37287033
DOI:
10.1186/s12957-023-03057-y
