mProX™ Human MST1R Stable Cell Line

[CAT#: S01YF-1023-PY89]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX478	Magic™ Human RON(MST1R) in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;TC71;TC32;Rh30

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Nasopharyngeal Carcinoma 3; Adenocarcinoma

Gene ID

Human:4486

UniProt ID

Human:Q04912

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

MST1R, also known as RON, is a gene that has been implicated in various diseases, including early-onset coronary artery disease, gastric cancer, selenium deficiency, and solid tumors. In the context of coronary artery disease, machine learning models have identified MST1R as a potentially novel risk gene that modulates immune signaling in response to cardiac stress. In gastric cancer, novel mutations in MST1R have been found, suggesting its involvement in gastric carcinogenesis. In the case of selenium deficiency, MST1R is one of the hub genes associated with receptor tyrosine kinase pathway, Wnt, and mTOR signaling pathways, which may play a role in cancer development. Additionally, MST1R has been identified as a potential target antigen for chimeric antigen receptor T cell therapy in solid tumors, including breast cancer, lung adenocarcinoma, and bladder cancer. Overall, MST1R has shown potential as a target for therapeutic interventions and as a biomarker for disease progression in various diseases.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Peyton Davis (Verified Customer)

What is the oncogenic function of MST1R/RON in cancer? Aug 24 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

MST1R/RON tyrosine kinase modifies multiple signaling pathways in epithelial and immune cells, modulating oncogenic phenotypes in various cancers. Aug 24 2020

chat Jordan Smith (Verified Customer)

How does MST1R influence breast cancer progression? Jun 11 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

Co-overexpression of MST1R and HGFL in breast cancer cells promotes tumorigenesis through autocrine and paracrine mechanisms. Jun 11 2021

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