MET
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers
| Full Name | MET proto-oncogene, receptor tyrosine kinase |
| Gene ID | Human: 4233 Mouse: 17295 Rat: 24553 Monkey: 704562 |
| UniProt ID | Human: P08581 Mouse: P16056 Rat: P97523 |
| Alternative Names | DA11; HGFR; AUTS9; RCCP2; c-Met; DFNB97;hepatocyte growth factor receptor;HGF receptor;HGF/SF receptor;SF receptor;proto-oncogene c-Met;scatter factor receptor;tyrosine-protein kinase Met |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MET Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: CHO-K1 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MET Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: CHO-S Assay Types: Functional assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MET Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: CT26 Assay Types: Functional assay and biological assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MET Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: MC-38 Assay Types: Functional assay and biological assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: TFG & MET Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: TPR & MET (Y1230H) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: BaF3 Assay Types: Functional assay and biological assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;MES-SA/Dx5
