Human TPR & MET Membrane Protein In Vitro Transcription (IVT) Plasmid
[CAT#: S01YF-1124-KX1149]
- Product Category:
- Membrane Protein Tools
- Subcategory:
- Membrane Protein Plasmids
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Product Information
Product Overview
This product is a made-to-order plasmid encoding human TPR & MET for In Vitro Transcription.
Target Protein
TPR; MET
Target Protein Species
Human
Target Classification
Kinases/Enzyme
Target Research Area
Cancer Research
Related Diseases
Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome; Differentiated Thyroid Carcinoma
Target Family
Kinases/Enzyme
Vector
pIVT
Vector Type
In Vitro Transcription (IVT) Vector
Note
Resistance
KanR
Growth Temperature
37°C
Relevant Promoters
T7
Mutation
Based on specific requirements
Expressed Tags
Based on specific requirements (Flag, StrepII, His, etc.)
Product Properties
Applications
In Vitro Transcription
Shipping
Blue Ice
Storage
Aliquot and store at -20°C for long term.
Target
Full Name
MET proto-oncogene, receptor tyrosine kinase
Introduction
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.
Alternative Names
MET; HGFR; AUTS9; RCCP2; c-Met; DFNB97; hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; MET proto-oncogene, receptor tyrosine kinase
Gene ID
UniProt ID
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