MAPK8
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
| Full Name | mitogen-activated protein kinase 8 |
| Gene ID | Human: 5599 Mouse: 26419 Rat: 116554 Monkey: 711115 |
| UniProt ID | Human: P45983 Mouse: Q91Y86 Rat: P49185 |
| Alternative Names | JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2;mitogen-activated protein kinase 8;JUN N-terminal kinase;MAP kinase 8;c-Jun N-terminal kinase 1;stress-activated protein kinase 1;stress-activated protein kinase 1c |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MAPK8 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: CHO-K1; HEK293
