mProX™ Human MAPK8 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Published Data
Fig.1 JNK promotes anoikis of murine epithelial cells.
LoxP/Mapk8 LoxP To produce Mapk8 −/− Mapk9 −/− cells (JNK KO), 4-hydroxytamoxifen was applied to Mapk9 −/− RosaCre ERT mouse kidney epithelial cells. Using immunoblot analysis, JNK expression in Control (RosaCre ERT) and JNK KO cells was investigated.
Ref: Girnius, Nomeda, and Roger J. Davis. "JNK promotes epithelial cell anoikis by transcriptional and post-translational regulation of BH3-only proteins." Cell reports 21.7 (2017): 1910-1921.
Pubmed: 29141222
DOI: 10.1016/j.celrep.2017.10.067
Research Highlights
MAPK8 activated the MAPK signaling pathway, which increased glioblastoma cells' resistance to TMZ, sped up cell proliferation, and prevented apoptosis.
Xu, Peng, et al. "MAPK8 mediates resistance to temozolomide and apoptosis of glioblastoma cells through MAPK signaling pathway." Biomedicine & Pharmacotherapy 106 (2018): 1419-1427.
Pubmed:
30119215
DOI:
10.1016/j.biopha.2018.06.084
By targeting MAPK8 and FAS, EGF inhibits the expression of miR-92a-1-5p, which may be regulated by STAT1/STAT3. This, in turn, enhances the expression of MMP-2/MMP-9 and controls the invasion of HTR-8/SVneo cells.
Malik, Ankita, Rahul Pal, and Satish Kumar Gupta. "EGF-mediated reduced miR-92a-1-5p controls HTR-8/SVneo cell invasion through activation of MAPK8 and FAS which in turn increase MMP-2/-9 expression." Scientific Reports 10.1 (2020): 12274.
Pubmed:
32703964
DOI:
10.1038/s41598-020-68966-4
