MAPK10
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
| Full Name | mitogen-activated protein kinase 10 |
| Gene ID | Human: 5602 Mouse: 26414 Rat: 25272 Monkey: 699736 |
| UniProt ID | Human: P53779 Mouse: Q61831 Rat: P49187 |
| Alternative Names | JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK;mitogen-activated protein kinase 10;JNK3 alpha protein kinase;MAP kinase 10;MAP kinase p49 3F12;c-Jun N-terminal kinase 3;stress activated protein kinase beta;stress-activated protein kinase 1b;stress-activated protein kinase JNK3 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MAPK10 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: Hep3B; HepG2; CHO-K1; HEK293
