mProX™ Human MAPK10 Stable Cell Line
[CAT#: S01YF-1123-KX276]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
MAPK10
Target Family
Kinases/Enzyme Drug Discovery Assays and Products
Target Protein Species
Human
Host Cell Type
Hep3B; HepG2; CHO-K1; HEK293
Target Classification
Kinase Cell Lines
Target Research Area
CNS Research
Related Diseases
Lennox-Gastaut Syndrome and Pertussis. Among its related pathways are MyD88 dependent cascade initiated on endosome and Prolactin Signaling
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
Humans have an enzyme called mitogen-activated protein kinase 10, or c-Jun N-terminal kinase 3 (JNK3), which is encoded by the MAPK10 gene. This gene codes for a protein that belongs to the family of MAP kinases. This protein is a kind of c-Jun N-terminal kinase (JNKs) that is exclusive to neurons. During neuronal death, this kinase regulates signaling pathways through its nuclear localization and phosphorylation. It has been discovered that beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, interacts with MAP kinase kinase 4 (MKK4) and promotes its phosphorylation. Cyclin-dependent kinase 5 has the ability to phosphorylate and inhibit this kinase's activity, which may be crucial in averting the death of neurons. There are four known alternatively spliced transcript variants that each encode a different isoform. The customized MAPK10 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
William
The MAPK10 cell line was easy to use, and the support team was responsive to our inquiries.
Jun 28 2020
Verified Customer
Carol
We used the MAPK10 KO cell line for target validation in our drug development project.
Jul 30 2021
Verified Customer
FAQ
Any questions about our products? Please visit our frequently asked questions page.
