MAP4K4
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
| Full Name | mitogen-activated protein kinase kinase kinase kinase 4 |
| Gene ID | Human: 9448 Mouse: 26921 Rat: 301363 Monkey: 716595 |
| UniProt ID | Human: O95819 Mouse: P97820 Rat: A0A097PIG6 |
| Alternative Names | HGK; NIK; MEKKK4; FLH21957; HEL-S-31; mitogen-activated protein kinase kinase kinase kinase 4; HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; Ste20 group protein kinase HGK; epididymis secretory protein Li 31; hepatocyte progenitor kinase-like/germinal center kinase-like kinase; nck-interacting kinase |
Product List
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Magic™ Human HGK(ZC1) Assay
[CAT#: S01YF-1122-KX1161]
- Product Category:
- Membrane Protein Drug Discovery In Vitro Assays
- Target Protein: HGK(ZC1) Target Family: Kinases/Enzyme Target Protein Species: Human Assay Types: Kinase Assay
mProX™ Human MAP4K4 Stable Cell Line
[CAT#: S01YF-1123-KX256]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MAP4K4 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: Capan-1; AsPC-1; CHO-K1; HEK293
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