mProX™ Human MAP4K4 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
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Published Data
Fig.1 MAP4K4 associates with MLK3 and regulates downstream signaling in PDAC.
Cells with knocked-down MLK3 showed downregulated p-JNK and p-c-Jun signals. When considered collectively, our findings show that there is interaction between MAP4K4 and MLK3, and that MAP4K4 regulates the MLK3-JNK axis upstream.
Ref: Singh, Sunil Kumar, et al. "MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3." Oncogene 40.43 (2021): 6153-6165.
Pubmed: 34511598
DOI: 10.1038/s41388-021-02007-w
Research Highlights
Important questions remain to be answered in this emerging and promising field of study, including figuring out which of the aforementioned effectors or other effectors mediates Map4k4 control of metabolic and vascular processes and figuring out Map4k4's upstream activators.
Virbasius, Joseph V., and Michael P. Czech. "Map4k4 signaling nodes in metabolic and cardiovascular diseases." Trends in Endocrinology & Metabolism 27.7 (2016): 484-492.
Pubmed:
27160798
DOI:
0.1016/j.tem.2016.04.006
In illness models, abnormal angiogenesis was decreased when MAP4K4 function was lost, suggesting MAP4K4 as a possible target for therapy.
Vitorino, Philip, et al. "MAP4K4 regulates integrin-FERM binding to control endothelial cell motility." Nature 519.7544 (2015): 425-430.
Pubmed:
25799996
DOI:
10.1038/nature14323
