MAP3K8
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.
| Full Name | mitogen-activated protein kinase kinase kinase 8 |
| Gene ID | Human: 1326 Mouse: 26410 Rat: 116596 Monkey: 696936 |
| UniProt ID | Human: P41279 Mouse: Q07174 Rat: Q63562 |
| Alternative Names | COT; EST; ESTF; TPL2; AURA2; MEKK8; Tpl-2; c-COT;mitogen-activated protein kinase kinase kinase 8;Ewing sarcoma transformant;augmented in rheumatoid arthritis 2;cot (cancer Osaka thyroid) oncogene;proto-oncogene c-Cot;proto-oncogene serine/threoine protein kinase;tumor progression locus 2 |
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mProX™ Human MAP3K8 Stable Cell Line
[CAT#: S01YF-1123-KX207]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MAP3K8 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: CHO-K1; HEK293
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