MAP3K5
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK
| Full Name | mitogen-activated protein kinase kinase kinase 5 |
| Gene ID | Human: 4217 Mouse: 26408 Rat: 365057 Monkey: 711382 |
| UniProt ID | Human: Q99683 Mouse: O35099 Rat: D3ZW27 |
| Alternative Names | ASK1; MEKK5; MAPKKK5;mitogen-activated protein kinase kinase kinase 5;ASK-1;MAP/ERK kinase kinase 5;MAPK/ERK kinase kinase 5;MEK kinase 5;MEKK 5;apoptosis signal-regulating kinase 1 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MAP3K5 Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: TEV protease Host Cell Type: HEK293 Assay Types: 14-3-3 assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MAP3K5 Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: TEV protease Host Cell Type: U2OS Assay Types: β-arrestin assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MAP3K5 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: CHO-K1; HEK293
