MAP3K3
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed
| Full Name | mitogen-activated protein kinase kinase kinase 3 |
| Gene ID | Human: 4215 Mouse: 26406 Rat: 303604 Monkey: 717866 |
| UniProt ID | Human: Q99759 Mouse: Q61084 Rat: B5DF98 |
| Alternative Names | MEKK3; MAPKKK3;mitogen-activated protein kinase kinase kinase 3;MAP/ERK kinase kinase 3;MAPK/ERK kinase kinase 3;MEK kinase 3;MEKK 3 |
Product List
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- Product Category:
- Membrane Protein Drug Discovery In Vitro Assays
- Target Protein: MAP3K3 Target Family: Kinases/Enzyme Target Protein Species: Human Assay Types: Kinase Assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MAP3K3 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: CNE-1; C666-1; CHO-K1; HEK293
