mProX™ Human MAP3K3 Stable Cell Line

[CAT#: S01YF-1123-KX293]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1203	Magic™ Human MAP3K3 in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

MAP3K3

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

CNE-1; C666-1; CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Verrucous Hemangioma and Cerebral Cavernous Malformations. Among its related pathways are Interleukin-1 family signaling and NGF Pathway

Gene ID

4215

UniProt ID

Q99759

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The MAP3K3 gene in humans encodes the enzyme mitogen-activated protein kinase kinase 3. This gene product is a polypeptide with 626 amino acids that is 96.5 percent similar to mouse MEKK3. Its catalytic domain bears close resemblance to the catalytic domains of tobacco NPK, yeast STE11, and mouse MEKK2. The control of cell destiny in response to external stimuli is a function of MAP3Ks. By activating SEK and MEK1/2, respectively, MAP3K3 directly regulates the pathways for stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK). It improved transcription from a reporter gene that was dependent on nuclear factor kappa-B (NF-κB) in cotransfection experiments, suggesting a function in the SAPK pathway. Different transcript variants with alternative splicing that encode different isoforms have been found. The customized MAP3K3 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Deborah

This is indeed a powerful MAP3K3 cell line. Sep 30 2022

chat Verified Customer

chat Laura

I can use the mouse MAP3K3 KO cell line to direct measurement when testing complex biological samples. Feb 02 2023

chat Verified Customer

FAQ

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