MAP3K20

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Full Name	mitogen-activated protein kinase kinase kinase 20
Gene ID	Human: 51776 Mouse: 65964 Rat: 311743 Monkey: 698274
UniProt ID	Human: Q9NYL2 Mouse: Q9ESL4 Rat: D4AE17
Alternative Names	pk; AZK; MLT; MRK; ZAK; CNM6; MLK7; MLTK; SFMMP; mlklak; MLTKbeta; MLTKalpha;mitogen-activated protein kinase kinase kinase 20;HCCS-4;MLK-like mitogen-activated protein triple kinase;ZAK1 homolog, leucine zipper and sterile-alpha motif kinase;human cervical cancer suppressor gene 4 protein;mitogen-activated protein kinase kinase kinase MLT;mixed lineage kinase 7;mixed lineage kinase with a leucine zipper and a sterile alpha motif;mixed lineage kinase-related kinase MRK-beta;sterile alpha motif and leucine zipper containing kinase AZK

Product List

mProX™ Human MAP3K20 Stable Cell Line [CAT#: S01YF-1023-PY137]

Product Category:: Membrane Protein Stable Cell Lines

Datasheet

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