MAP3K20
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
| Full Name | mitogen-activated protein kinase kinase kinase 20 |
| Gene ID | Human: 51776 Mouse: 65964 Rat: 311743 Monkey: 698274 |
| UniProt ID | Human: Q9NYL2 Mouse: Q9ESL4 Rat: D4AE17 |
| Alternative Names | pk; AZK; MLT; MRK; ZAK; CNM6; MLK7; MLTK; SFMMP; mlklak; MLTKbeta; MLTKalpha;mitogen-activated protein kinase kinase kinase 20;HCCS-4;MLK-like mitogen-activated protein triple kinase;ZAK1 homolog, leucine zipper and sterile-alpha motif kinase;human cervical cancer suppressor gene 4 protein;mitogen-activated protein kinase kinase kinase MLT;mixed lineage kinase 7;mixed lineage kinase with a leucine zipper and a sterile alpha motif;mixed lineage kinase-related kinase MRK-beta;sterile alpha motif and leucine zipper containing kinase AZK |
Product List
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Magic™ Human ZAK Assay
[CAT#: S01YF-1222-KX532]
- Product Category:
- Membrane Protein Drug Discovery In Vitro Assays
- Target Protein: ZAK Target Family: Kinases/Enzyme Target Protein Species: Human Assay Types: Kinase Assay
mProX™ Human MAP3K20 Stable Cell Line
[CAT#: S01YF-1023-PY137]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;C2C12 Assay Types: Biological assays
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