mProX™ Human MAP3K20 Stable Cell Line

[CAT#: S01YF-1023-PY137]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1222-KX532	Magic™ Human ZAK in Vitro Assay	Human		Kinase Assay

Product Information

Target Family

Kinases/Enzyme

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;C2C12

Target Classification

Kinase Cell Lines

Target Research Area

Immunology Research

Related Diseases

Split-Foot Malformation With Mesoaxial Polydactyly; Myopathy, Centronuclear, 6, With Fiber-Type Disproportion

Gene ID

Human:51776

UniProt ID

Human:Q9NYL2

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

MAP3K20, also known as mitogen-activated protein kinase kinase kinase 20, is involved in various biological processes and pathways. In the context of preadipocyte differentiation, MAP3K20 is one of the genes that lost the H3K9ac signal in its TSS region and had low mRNA expression. It plays a role in the regulation of lipid deposition and adipocyte differentiation. In the study of myofibrillar myopathy, MAP3K20 is not directly implicated, but its involvement in the "MAPK signaling" pathway is identified through ChIP-seq and mRNA-seq assays. In lung adenocarcinoma, a prognostic signature based on cuproptosis-related lncRNAs includes MAP3K20-AS1 as one of the potentially high-risk CRlncRNAs. Finally, in the study of muscle development in cattle, MAP3K20 is identified as one of the potential target genes of the transcription factor MEF2C, suggesting its involvement in skeletal muscle development. Overall, MAP3K20 is implicated in adipocyte differentiation, MAPK signaling, lung adenocarcinoma prognosis, and skeletal muscle development.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Alex Brown (Verified Customer)

What genetic conditions are associated with MAP3K20 mutations? May 19 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

Mutations in MAP3K20 have been linked to centronuclear myopathy-6 with fiber-type disproportion and split-foot malformation with sensorineural hearing loss. May 19 2023

chat Casey Williams (Verified Customer)

How does MAP3K20 influence gastric cancer? Mar 13 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

Knockdown of MAP3K20 antisense RNA 1 inhibits gastric cancer growth by epigenetically regulating miR-375. Mar 13 2020

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