MAP2K4
This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants
| Full Name | mitogen-activated protein kinase kinase 4 |
| Gene ID | Human: 6416 Mouse: 26398 Rat: 287398 Monkey: 718155 |
| UniProt ID | Human: P45985 Mouse: P47809 Rat: S4VP54 |
| Alternative Names | JNKK; MEK4; MKK4; SEK1; SKK1; JNKK1; SERK1; MAPKK4; PRKMK4; SAPKK1; SAPKK-1;dual specificity mitogen-activated protein kinase kinase 4;JNK-activated kinase 1;JNK-activating kinase 1;MAP kinase kinase 4;MAPK/ERK kinase 4;MAPKK 4;MEK 4;SAPK/ERK kinase 1;c-Jun N-terminal kinase kinase 1;stress-activated protein kinase kinase 1 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MAP2K4 Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: TEV protease Host Cell Type: U2OS Assay Types: β-arrestin assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MAP2K4 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: AsPC-1; CHO-K1; HEK293
