mProX™ Human MAP2K4 Stable Cell Line
[CAT#: S01YF-1123-KX290]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
MAP2K4
Target Family
Kinases/Enzyme Drug Discovery Assays and Products
Target Protein Species
Human
Host Cell Type
AsPC-1; CHO-K1; HEK293
Target Classification
Kinase Cell Lines
Target Research Area
Digestive and Renal Research; Infectious Research
Related Diseases
Anthrax Disease and Ureteral Obstruction. Among its related pathways are MyD88 dependent cascade initiated on endosome and Prolactin Signaling.
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
The human MAP2K4 gene encodes the enzyme dual-specificity mitogen-activated protein kinase kinase 4. A dual-specificity kinase from the Ser/Thr protein kinase family is encoded by MAP2K4. When confronted with different environmental stressors or mitogenic stimuli, MAP2K4 phosphorylates MAP kinases. MAP2K4 substrates include MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38; however, MAP2K4 does not phosphorylate MAPK1/ERK2 or MAPK3/ERK1. From a structural perspective, MAP2K4 has a kinase domain that MAP3K1 phosphorylates and activates. Numerous phosphorylated and ubiquitinated amino acid sites are present in MAP2K4. Map2k4 knockout mice were used in genetic investigations that demonstrated poor hepatogenesis, faulty liver development, and embryonic mortality. The customized MAP2K4 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Sarah
The MAP2K4 KD cell line is easy to use and has become an essential tool in my lab.
Mar 03 2021
Verified Customer
Helen
The MAP2K4 cell line allowed me to perform rigorous experiments with consistent results.
Mar 09 2023
Verified Customer
FAQ
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