MAP2K3
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene
| Full Name | mitogen-activated protein kinase kinase 3 |
| Gene ID | Human: 5606 Mouse: 26397 Rat: 303200 Monkey: 705195 |
| UniProt ID | Human: P46734 Mouse: O09110 Rat: B1H230 |
| Alternative Names | MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2;dual specificity mitogen-activated protein kinase kinase 3;MAP kinase kinase 3;MAPK/ERK kinase 3;MAPKK 3;MEK 3;SAPK kinase 2;stress-activated protein kinase kinase 2 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MAP2K3 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: DLBCL; CHO-K1; HEK293
