MAP2K2
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene
| Full Name | mitogen-activated protein kinase kinase 2 |
| Gene ID | Human: 5605 Mouse: 26396 Rat: 58960 Monkey: 721821 |
| UniProt ID | Human: P36507 Mouse: Q63932 Rat: P36506 |
| Alternative Names | CFC4; MEK2; MKK2; MAPKK2; PRKMK2;dual specificity mitogen-activated protein kinase kinase 2;ERK activator kinase 2;MAP kinase kinase 2;MAPK/ERK kinase 2;mitogen-activated protein kinase kinase 2, p45 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: MAP2K2 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: SW839; Caki; CHO-K1; HEK293
