LIMK1
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
| Full Name | LIM domain kinase 1 |
| Gene ID | Human: 3984 Mouse: 16885 Rat: 65172 Monkey: 699494 |
| UniProt ID | Human: P53667 Mouse: P53668 Rat: P53669 |
| Alternative Names | LIMK; LIMK-1;LIM domain kinase 1;LIM motif-containing protein kinase |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: LIMK1 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: CHO-K1; HEK293
