LILRB3
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
| Full Name | Leukocyte immunoglobulin like receptor B3 |
| Gene ID | Human: 11025 Rat: 308350 Monkey: 106992409 |
| UniProt ID | Human: O75022 Mouse: P97484 Rat: M0RCP1 Monkey: F6VWN7 |
| Alternative Names | LILRB3; HL9; ILT5; LIR3; PIRB; CD85A; ILT-5; LIR-3; PIR-B; LILRA6; leukocyte immunoglobulin-like receptor subfamily B member 3; CD85 antigen-like family member A; immunoglobulin-like transcript 5; leucocyte Ig-like receptor B3; leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3; monocyte inhibitory receptor HL9; Leukocyte immunoglobulin like receptor B3 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: LILRB3 Target Family: Oncology Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: CHO-K1 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: LILRB3 Target Family: Oncology Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: HEK293T Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Oncology Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;Molm13
