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    mProX™ Human LILRB3 Stable Cell Line

    [CAT#: S01YF-1023-PY237]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Oncology Cell Lines

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    Host Cell Type:
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    Product Information

    Target Family
    Oncology
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;Molm13
    Target Classification
    Oncology Cell Lines
    Target Research Area
    CNS Research
    Related Diseases
    Anencephaly; Takayasu Arteritis
    Gene ID
    Human:11025
    UniProt ID
    Human:C9JWL8

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    LILRB3, also known as leukocyte immunoglobulin-like receptor B3, has various applications in different fields. In the context of glioma, LILRB3 has been found to suppress immunity and is associated with poor prognosis. In a study on immune-associated mRNA expression, LILRB3 was one of the mRNAs found to be increased after Baker's yeast beta glucan supplementation, which supports the immune system and reduces susceptibility to infection. In the study of tropical pulmonary eosinophilia, LILRB3 was identified as one of the negative regulators of the immune response, playing a role in promoting lung damage. In a case of diffuse large B-cell lymphoma, LILRB3 was expressed in tumor-associated macrophages and was associated with poor prognosis. Additionally, LILRB3 has been identified as a putative cell surface receptor of APOE4, one of the isoforms of apolipoprotein E, and its interaction with APOE4 activates microglia cells into a pro-inflammatory state. These findings suggest that LILRB3 has implications in immune regulation, cancer prognosis, and neuroinflammation.

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    FAQ

    chat Cameron Jones (Verified Customer)

    How does LILRB3 affect acute myeloid leukemia development? Nov 25 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    LILRB3 modulates acute myeloid leukemia (AML) cell survival and antileukemic T-cell responses through the TRAF2-cFLIP-NF-κB signaling axis, indicating its role in AML progression and immune evasion. Nov 25 2021

    chat Skyler Garcia (Verified Customer)

    What is the role of LILRB3 in epithelial cell behavior? Jan 19 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    LILRB3 expressed on non-transformed epithelial cells recognizes MHC class I on transformed cells, triggering their extrusion, which is a mechanism for removing precancerous cells. Jan 19 2021

    Related Products by Target
    • Magic™ Human LILRB3 CHO-K1 Cell Line (CAT#: S01YF-0123-KX168)
    • mProX™ Human LILRB3 Stable Cell Line (CAT#: S01YF-1023-PY237)
    • Magic™ Human LILRB3 HEK293T Cell Line (CAT#: S01YF-0123-KX167)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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