LIFR
This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding two different isoforms have been found for this gene.
| Full Name | LIF receptor subunit alpha |
| Gene ID | Human: 3977 Mouse: 16880 Rat: 81680 Monkey: 694139 |
| UniProt ID | Human: P42702 Mouse: P42703 Rat: O70535 Monkey: F7E0D3 |
| Alternative Names | LIFR; SWS; SJS2; STWS; CD118; LIF-R; leukemia inhibitory factor receptor; CD118 antigen; LIF receptor alpha; leukemia inhibitory factor receptor alpha; LIF receptor subunit alpha |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: LIFR Target Family: Others Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: HEK293T Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Other Targets Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;Huh-7;HepG2
