Recommended
Membrane Protein Drug Discovery In Vitro Assays Membrane Protein In Vitro Assay Kits Membrane Protein Stable Cell Lines Membranes Membrane Protein Virus Particles Membrane Staining and Imaging Reagents
  1. Home
  2. LIFR
  3. mProX™ Human LIFR Stable Cell Line
product-img
  • Products
  • Discover MP Targets
  • Discover Research Areas
    • 1- Membrane Protein Stable Cell Line-DiscoverMP Membrane Protein Stable Cell Line, Drug Discovery Tools
    1- Membrane Protein Stable Cell Line-DiscoverMP Other Cell Lines,Drug Discovery Tools

    mProX™ Human LIFR Stable Cell Line

    [CAT#: S01YF-1023-PY275]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

    Datasheet MSDS Request COA

    Certificate of Analysis Lookup
    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
    Lot Number

    Bulk Quote

    Made to Order Inquiry

    Inquiry
    Host Cell Type:
    Membrane Protein Engineering:
    Fluorescent Marker:
    Resistance:
    Deliverable:

    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;Huh-7;HepG2
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Orphan Receptor Research
    Related Diseases
    Stuve-Wiedemann Syndrome 1; Cakut
    Gene ID
    Human:3977
    UniProt ID
    Human:P42702

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    Leukemia inhibitory factor receptor (LIFR) has been implicated in various biological processes and diseases. In a study on smooth muscle cell (SMC) proliferation and migration, it was found that LIFR and glycoprotein 130 (gp130) play a role in cardiotrophin-1 (CT-1) induced effects. Additionally, LIFR was shown to physically associate with RECK, a membrane-anchored MMP inhibitor, inhibiting the effects of CT-1. Another study investigated the modulation of LIF in dental pulp inflammation, revealing that LIF aggravates pulpitis by promoting macrophage inflammatory response through a STAT3/p65-dependent pathway. Furthermore, LIF was found to play a crucial role in driving the recruitment of macrophages to inflamed pulp tissue. These findings suggest the potential therapeutic use of LIFR in vascular diseases characterized by SMC proliferation and migration, as well as in the regulation of inflammation in dental pulp.

    Protocols

    Please visit our protocols page.

    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human LIFR Stable Cell Line (S01YF-1023-PY275). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Alex Davis (Verified Customer)

    How does LIFR influence breast cancer metastasis? May 16 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    LIFR acts as a metastasis suppressor in breast cancer, functioning downstream of miR-9 microRNA and upstream of Hippo signaling, impacting cancer cell metastasis. May 16 2022

    chat Alex Davis (Verified Customer)

    What is the role of LIFR in embryonic implantation and development? Dec 16 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    LIFR is implicated in the development of endometrial receptivity for trophoblast growth, apposition, and adhesion in mares, suggesting its importance in embryonic development and implantation. Dec 16 2020

    Related Products by Target
    • Magic™ Human LIFR HEK293T Cell Line (CAT#: S01YF-0123-KX195)
    • mProX™ Human LIFR Stable Cell Line (CAT#: S01YF-1023-PY275)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
    Send Inquiry Send Inquiry
    Inquiry Basket
    compare

    Go to compare