LCK
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described.
| Full Name | LCK proto-oncogene, Src family tyrosine kinase |
| Gene ID | Human: 3932 Mouse: 16818 Rat: 313050 Monkey: 717704 |
| UniProt ID | Human: P06239 Mouse: P06240 Rat: Q01621 |
| Alternative Names | LSK; YT16; IMD22; p56lck; pp58lck;tyrosine-protein kinase Lck;T-lymphocyte specific protein tyrosine kinase p56lck;leukocyte C-terminal Src kinase;lymphocyte cell-specific protein-tyrosine kinase;p56(LSTRA) protein-tyrosine kinase;proto-oncogene tyrosine-protein kinase LCK;t cell-specific protein-tyrosine kinase |
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mProX™ Human LCK Stable Cell Line
[CAT#: S01YF-1123-KX282]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: LCK Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: Ba/F3; CHO-K1; HEK293
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