mProX™ Human LCK Stable Cell Line
[CAT#: S01YF-1123-KX282]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
LCK
Target Family
Kinases/Enzyme Drug Discovery Assays and Products
Target Protein Species
Human
Host Cell Type
Ba/F3; CHO-K1; HEK293
Target Classification
Kinase Cell Lines
Target Research Area
Cancer Research; Immunology Research
Related Diseases
Immunodeficiency 22 and T-Cell Acute Lymphoblastic Leukemia. Among its related pathways are CD28 co-stimulation and "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
The 56 kDa protein Lck is present in lymphocytes, which are specific immune system cells. As a member of the Src kinase family (SFK), Lck plays a crucial role in naive T cells as well as effector T cells in activating T-cell receptor signaling. Compared to CD4 T cells, the activation or maintenance of memory CD8 T cells is less dependent on the Lck. Additionally, different memory T cell subsets have different roles for the lck. It appears that in mice, among the population of effector memory T cells, over 50% of lck exists in a constitutively active conformation, while less than 20% of lck exists in an active form. The customized LCK stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Linda
A very stable LCK KD cell line, especially as there has not been much variation change during my use.
Dec 25 2022
Verified Customer
John
If you are looking for a good value LCK cell line for drug discovery, this is the one.
Jul 11 2022
Verified Customer
FAQ
Any questions about our products? Please visit our frequently asked questions page.
