LATS1
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
| Full Name | large tumor suppressor kinase 1 |
| Gene ID | Human: 9113 Mouse: 16798 Rat: 308265 Monkey: 696131 |
| UniProt ID | Human: O95835 Mouse: Q8BYR2 Rat: F1M2K4 |
| Alternative Names | wts; WARTS;serine/threonine-protein kinase LATS1;LATS (large tumor suppressor, Drosophila) homolog 1;LATS, large tumor suppressor, homolog 1;WARTS protein kinase;h-warts;large tumor suppressor homolog |
Product List
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- Product Category:
- Membrane Protein Drug Discovery In Vitro Assays
- Target Protein: LATS1 Target Family: Kinases/Enzyme Target Protein Species: Human Assay Types: Kinase Assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: LATS1 Host Cell Type: THP-1
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: LATS1 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: Huh7;CHO-K1; HEK293
