mProX™ Human LATS1 Stable Cell Line

[CAT#: S01YF-1123-KX280]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Kinase Cell Lines

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Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX1188	Magic™ Human LATS1 in Vitro Assay	Human		Kinase Assay

Product Information

Target Protein

LATS1

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

Huh7;CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Malignant Peritoneal Mesothelioma and Tetraploidy. Among its related pathways are Hippo-Merlin signaling dysregulation and DNA IR-double strand breaks and cellular response via ATM

Gene ID

9113

UniProt ID

O95835

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The LATS1 gene in humans encodes the enzyme large tumor suppressor kinase 1 (LATS1). The Hippo signaling pathway has been linked to it, as it phosphorylates TAZ and YAP to render them inactive. A putative serine/threonine kinase that localizes to the mitotic apparatus and forms a complex with cell cycle controller CDC2 kinase during early mitosis is the protein that this gene encodes. The cell cycle determines how the protein is phosphorylated, with late prophase phosphorylation persisting until metaphase. With its binding to CDC2, the protein's N-terminal region forms a complex that exhibits decreased histone H1 kinase activity, suggesting that it functions as a negative regulator of CDC2/cyclin A. The customized LATS1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Joseph

Reliable and repeatable LATS1 cell line. Jan 05 2021

chat Verified Customer

chat Brian

I highly recommend the human LATS1 cell line for anyone working on membrane protein research. Nov 17 2022

chat Verified Customer

FAQ

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