KCNJ3
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins.
| Full Name | Potassium inwardly rectifying channel subfamily J member 3 |
| Gene ID | Human: 3760 Mouse: 16519 Rat: 50599 Monkey: 696473 |
| UniProt ID | Human: P48549 Mouse: P63250 Rat: P63251 Monkey: F7ERG6 |
| Alternative Names | KGA; GIRK1; KIR3.1; G protein-activated inward rectifier potassium channel 1; GIRK-1; inward rectifier K(+) channel Kir3.1; inward rectifier K+ channel KIR3.1; potassium channel, inwardly rectifying subfamily J member 3; potassium inwardly-rectifying channel subfamily J member 3 splice variant 1e; potassium voltage-gated channel subfamily J member 3; KCNJ3; Potassium inwardly rectifying channel subfamily J member 3 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KCNJ3/KCNJ5 Target Family: Inwardly Rectifying Potassium Channel Target Protein Species: Human
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KCNJ3 Target Family: GIRK Target Protein Species: Human Host Cell Type: CHO-K1; HEK293
