JAK1
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants.
| Full Name | Janus kinase 1 |
| Gene ID | Human: 3716 Mouse: 16451 Rat: 84598 Monkey: 677689 |
| UniProt ID | Human: P23458 Mouse: P52332 Rat: O35803 |
| Alternative Names | JTK3; AIIDE; JAK1A; JAK1B;tyrosine-protein kinase JAK1 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: JAK1 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: CHO-K1; HEK293
