mProX™ Human JAK1 Stable Cell Line
[CAT#: S01YF-1123-KX271]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
JAK1
Target Family
Kinases/Enzyme Drug Discovery Assays and Products
Target Protein Species
Human
Host Cell Type
CHO-K1; HEK293
Target Classification
Kinase Cell Lines
Target Research Area
Immunology Research; Inflammation Research; Reproductive Research
Related Diseases
Autoinflammation, Immune Dysregulation, And Eosinophilia and Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Jak1 Deficiency. Among its related pathways are IL-9 Signaling Pathways and Overview of interferons-mediated signaling pathway
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
Human tyrosine kinase JAK1 is required for the signaling of some type I and type II cytokines. It elicits signals from the gp130 receptor family, IL-2, IL-4, CNTF-R, NNT-1R, and Leptin-R families by interacting with the common gamma chain (γc) of type I cytokine receptors. It is also crucial for the type II cytokine receptor-mediated transduction of a signal by type I and type II interferons and the IL-10 family. When it comes to triggering reactions to various key cytokine receptor families, Jak1 is indispensable. In neonatal mice, loss of Jak1 results in death, potentially as a result of difficulty nursing. Cancer cells that express JAK1 can contract, which may allow the cells to spread beyond the tumor and invade other areas of the body. The customized JAK1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Melissa
This JAK1 KD cell line has saved us time and resources. Our team is excited to delve deeper into our investigations.
Jun 13 2023
Verified Customer
Shirley
I think this JAK1 KD cell line is better than many similar products already on the market.
Aug 18 2023
Verified Customer
FAQ
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