IL21R
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
| Full Name | Interleukin 21 receptor |
| Gene ID | Human: 50615 Mouse: 60504 Rat: 308977 Monkey: 705759 |
| UniProt ID | Human: Q9HBE5 Mouse: Q9JHX3 Rat: A0A8I6AER5 Monkey: F7HDU9 |
| Alternative Names | IL21R; NILR; CD360; IMD56; interleukin-21 receptor; IL-21 receptor; novel interleukin receptor; Interleukin 21 receptor |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: IL21R Target Family: Immune Checkpoint Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: IL21R Target Family: Immune Checkpoint Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Immune Checkpoint Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;MKN45;HGC27
