mProX™ Human IL21R Stable Cell Line

Product Information

Target Family

Immune Checkpoint

Target Protein Species

Human

Host Cell Type

HEK293;CHO-K1;MKN45;HGC27

Target Classification

Immune Checkpoint Cell Lines

Target Research Area

Immunology Research

Related Diseases

Immunodeficiency 56; Ige Responsiveness, Atopic

Gene ID

Human:50615

UniProt ID

Human:Q9HBE5

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

IL21R, also known as interleukin-21 receptor, has various applications in different fields of research. In the context of ulcerative colitis (UC), IL21R has been identified as a gene specific to a subgroup of UC patients. This finding can aid in the development of diagnostic methods and personalized treatment strategies for UC. In primary biliary cholangitis (PBC), IL21R has been identified as a target gene of GTF2I, a susceptibility gene for PBC. Understanding the mechanism of IL21R in PBC can contribute to the identification of new therapeutic targets. IL21R has also been studied in the context of flu vaccine response in aging individuals and those with SIV infection. IL-21-IgFc immunotherapy has been shown to enhance flu vaccine response by altering the transcriptional landscape of lymph node cells. Additionally, IL21R is required for the maintenance and pathogenesis of murine IL-17-producing Œ≥Œ¥T cells. IL-21 treatment has been found to modulate the inductive lymph node germinal center activity and reverse Tfh and B-cell dysfunction. Furthermore, IL-21/IL-21R has been shown to promote the pro-inflammatory effects of macrophages during respiratory infection. These findings highlight the diverse applications of IL21R in different disease contexts and provide insights into its role in disease pathogenesis and treatment.

Protocols

Please visit our protocols page.

Customer Reviews

There are currently no Customer reviews or questions for mProX™ Human IL21R Stable Cell Line (S01YF-1023-PY192). Click the button above to contact us or submit your feedback about this product.

FAQ

chat Jordan Johnson (Verified Customer)

What is the role of IL21R in immune responses? Jun 15 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

IL21R is involved in regulating immune responses, particularly in the context of infections and immune-mediated diseases. Jun 15 2023

chat Morgan Williams (Verified Customer)

How does IL21R affect cancer immunity? Dec 21 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

IL21R can mediate angiogenesis without inducing vascular leakage, suggesting its potential role in cancer immunity and therapeutic angiogenesis. Dec 21 2022

Published Data

Fig.1 Cell proliferation is suppressed by the knockdown of IL-21R.

In these two cell lines, experiments were conducted to investigate the function, whereby siRNA-mediated knockdown procedures were employed. Following transfection with either siIL-21R or NC, a significant reduction in both mRNA and protein levels of IL-21R was observed within these cells. Subsequently, a decrease in cell proliferative activities was demonstrated through CCK-8 assay upon the knockdown of IL-21R.

Ref: Yan, Lei, et al. "IL-21R functions as an oncogenic factor and is regulated by the lncRNA MALAT1/miR-125a-3p axis in gastric cancer." International Journal of Oncology 54.1 (2019): 7-16.

Pubmed: 30387833

DOI: 10.3892/ijo.2018.4612

Research Highlights

Ma, J-L. et al. "Construction of molecular subgroups of ulcerative colitis." European review for medical and pharmacological sciences, 2023.
Ulcerative colitis (UC) is a chronic inflammatory disease of the colon, the etiology of which remains unknown. The condition is characterized by periods of remission and recurrence. Unfortunately, a significant number of cases of UC are either misdiagnosed or experience delays in diagnosis and treatment. The purpose of this study was to identify genes related to UC in order to facilitate the development of effective drugs for this condition.
Ma, J-L. et al. "Construction of molecular subgroups of ulcerative colitis." European review for medical and pharmacological sciences, 2023.
Pubmed: 37843347 DOI: 10.26355/eurrev_202310_33961

Wu, Ziyan. et al. "ChIP-seq analysis found IL21R, a target gene of GTF2I-the susceptibility gene for primary biliary cholangitis in Chinese Han." Hepatology international, 2023.
This study aimed to identify a novel susceptibility gene linked to primary biliary cholangitis (PBC) among the Chinese Han population and to further examine the potential mechanism underlying this gene's role in PBC. The researchers utilized genetic analysis techniques to identify and confirm the gene's involvement and studied its function in the context of PBC. This investigation provides valuable insights into the pathogenesis of PBC and may lead to novel therapeutic strategies for this chronic autoimmune liver disease.
Wu, Ziyan. et al. "ChIP-seq analysis found IL21R, a target gene of GTF2I-the susceptibility gene for primary biliary cholangitis in Chinese Han." Hepatology international, 2023.
Pubmed: 37713154 DOI: 10.1007/s12072-023-10586-x