mProX™ Human IL21R Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

IL21R, also known as interleukin-21 receptor, has various applications in different fields of research. In the context of ulcerative colitis (UC), IL21R has been identified as a gene specific to a subgroup of UC patients. This finding can aid in the development of diagnostic methods and personalized treatment strategies for UC. In primary biliary cholangitis (PBC), IL21R has been identified as a target gene of GTF2I, a susceptibility gene for PBC. Understanding the mechanism of IL21R in PBC can contribute to the identification of new therapeutic targets. IL21R has also been studied in the context of flu vaccine response in aging individuals and those with SIV infection. IL-21-IgFc immunotherapy has been shown to enhance flu vaccine response by altering the transcriptional landscape of lymph node cells. Additionally, IL21R is required for the maintenance and pathogenesis of murine IL-17-producing γδT cells. IL-21 treatment has been found to modulate the inductive lymph node germinal center activity and reverse Tfh and B-cell dysfunction. Furthermore, IL-21/IL-21R has been shown to promote the pro-inflammatory effects of macrophages during respiratory infection. These findings highlight the diverse applications of IL21R in different disease contexts and provide insights into its role in disease pathogenesis and treatment.