GDF15
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress.
| Full Name | Growth differentiation factor 15 |
| Gene ID | "Human: 9518 Mouse: 23886 Rat: 29455 Monkey: 719466" |
| UniProt ID | Human: Q99988 Mouse: Q9Z0J7 Rat: Q9Z0J6 Monkey: G7PWZ3 |
| Alternative Names | PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15; NRG-1; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; PTGF-beta; macrophage inhibitory cytokine 1; non-steroidal anti-inflammatory drug-activated gene-1; placental TGF-beta; placental bone morphogenetic protein; prostate differentiation factor |
Product List
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Magic™ Human GDF15 & CD274 CT26 Cell Line
[CAT#: S01YF-0324-KX54]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: GDF15 & CD274 Target Family: Others Target Protein Species: Human Host Cell Type: CT26 Assay Types: Functional assay and biological assay
Magic™ Human GDF15 & CD274 MC-38 Cell Line
[CAT#: S01YF-0324-KX113]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: GDF15 & CD274 Target Family: Others Target Protein Species: Human Host Cell Type: MC-38 Assay Types: Functional assay and biological assay
Magic™ Human GDF15 CT26 Cell Line
[CAT#: S01YF-0123-KX84]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: GDF15 Target Family: Others Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: CT26 Assay Types: Drug screening and biological assays
Magic™ Human GDF15 MC-38 Cell Line
[CAT#: S01YF-0123-KX85]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: GDF15 Target Family: Others Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: MC-38 Assay Types: Drug screening and biological assays
mProX™ Human GDF15 Stable Cell Line
[CAT#: S01YF-1023-PY272]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Family: Other Targets Target Protein Species: Human Host Cell Type: HEK293;CHO-K1;HeLa;HT-3
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