GALR2
Galanin is a crucial neuromodulator found in the hypothalamopituitary axis, gastrointestinal tract, and brain. It is a 30-amino acid non-C-terminally amidated peptide that effectively increases the release of growth hormone, prevents cardiac vagal heart rate slowing, eliminates sinus arrhythmia, and reduces postprandial gastrointestinal motility. Galanin interacts with particular membrane receptors that belong to the 7-transmembrane family of G protein-coupled receptors to exert its effects. The galanin peptide's N-terminal residues interact with GALR2. The phospholipase C/protein kinase C pathway serves as GALR2's main signaling pathway (via Gq). However, it has been shown that GALR2 effectively links to both the Gq and Gi proteins, activating 2 separate signaling pathways at once.
| Full Name | Galanin receptor 2 |
| Gene ID | Human: 8811 Mouse: 14428 Rat: 29234 Monkey: 705684 |
| UniProt ID | Human: O43603 Mouse: O88854 Rat: O08726 Monkey: A0A2K5WWW1 |
| Alternative Names | GAL2-R; GALNR2; GALR-2; galanin receptor type 2; GALR2; Galanin receptor 2 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: GALR2 Target Family: Galanin Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: CHO-K1 Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: GALR2 Target Family: Galanin Receptor Target Protein Species: Human Host Cell Type: CHO-K1 Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: GALR2 Target Family: Galanin Receptor Target Protein Species: Human Host Cell Type: CHO-K1 Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: GALR2 Target Family: Galanin Receptor Target Protein Species: Human Host Cell Type: CHO-K1 Assay Types: Binding and Functional Assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: GALR2 Target Family: Galanin Receptor Target Protein Species: Human Host Cell Type: U2OS Assay Types: Reporter Assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: GALR2 Target Family: Galanin Family Target Protein Species: Rat Host Cell Type: H9C2;CHO-K1;HEK293
