FGR
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.
| Full Name | FGR proto-oncogene, Src family tyrosine kinase |
| Gene ID | Human: 2268 Mouse: 14191 Rat: 79113 Monkey: 716296 |
| UniProt ID | Human: P09769 Mouse: P14234 Rat: Q6P6U0 |
| Alternative Names | SRC2; c-fgr; c-src2; p55-Fgr; p58-Fgr; p55c-fgr; p58c-fgr;tyrosine-protein kinase Fgr;Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog;c-fgr protooncogene;c-src-2 proto-oncogene;feline Gardner-Rasheed sarcoma viral oncogene homolog;p55-c-fgr protein;proto-oncogene c-Fgr;proto-oncogene tyrosine-protein kinase FGR;v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog |
Product List
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mProX™ Human FGR Stable Cell Line
[CAT#: S01YF-1123-KX241]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FGR Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: HL-60; CHO-K1; HEK293
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