FGFR1
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
| Full Name | fibroblast growth factor receptor 1 |
| Gene ID | Human: 2260 Mouse: 14182 Rat: 79114 Monkey: 700126 |
| UniProt ID | Human: P11362 Mouse: P16092 Rat: Q04589 |
| Alternative Names | CEK; FLG; HH2; OGD; ECCL; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-;fibroblast growth factor receptor 1;FGFR1/PLAG1 fusion;FMS-like tyrosine kinase 2;basic fibroblast growth factor receptor 1;fms-related tyrosine kinase 2;heparin-binding growth factor receptor;hydroxyaryl-protein kinase;proto-oncogene c-Fgr |
Product List
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- Product Category:
- Membrane Protein Tools
- Target Protein: FGFR1 Target Family: Kinases/Enzyme Vector: pBE Vector Type: Bacterial Expression Vector
- Product Category:
- Membrane Protein Tools
- Target Protein: FGFR1 Target Family: Kinases/Enzyme RNA Type: IVT mRNA Formation: In Vitro Transcription (IVT) mRNA
- Product Category:
- Membrane Protein Tools
- Target Protein: FGFR1 Target Family: Kinases/Enzyme Vector: pIVT Vector Type: In Vitro Transcription (IVT) Vector
- Product Category:
- Membrane Protein Tools
- Target Protein: FGFR1 Target Family: Kinases/Enzyme Vector: pIE Vector Type: Insect Expression Vector
- Product Category:
- Membrane Protein Tools
- Target Protein: FGFR1 Target Family: Kinases/Enzyme Vector: pLV Vector Type: Lentiviral Expression Vector
- Product Category:
- Membrane Protein Tools
- Target Protein: FGFR1 Target Family: Kinases/Enzyme
- Product Category:
- Membrane Protein Tools
- Target Protein: FGFR1 Target Family: Kinases/Enzyme RNA Type: LNP-mRNA Formation: LNP Encapsulation mRNA
- Product Category:
- Membrane Protein Tools
- Target Protein: FGFR1 Target Family: Kinases/Enzyme Vector: pME Vector Type: Mammalian Transient Expression Vector
- Product Category:
- Membrane Protein Tools
- Target Protein: FGFR1 Target Family: Kinases/Enzyme Vector: pRV Vector Type: Retroviral Expression Vector
- Product Category:
- Membrane Protein Tools
- Target Protein: FGFR1 Target Family: Kinases/Enzyme Vector: pYE Vector Type: Yeast Expression Vector
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & FGFR1 (K656E) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: Ba/F3 Assay Types: Functional assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & FGFR1 (K656N) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: Ba/F3 Assay Types: Functional assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & FGFR1 (N546K) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: Ba/F3 Assay Types: Functional assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & FGFR1 (V561F) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: Ba/F3 Assay Types: Functional assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: BCR & FGFR1 (V561M) Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: Ba/F3 Assay Types: Functional assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: FGFR1 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: NSCLC; CHO-K1; HEK293
