mProX™ Human FGFR1 Stable Cell Line

Product Information

Target Protein

FGFR1

Target Family

Kinases/Enzyme Drug Discovery Assays and Products

Target Protein Species

Human

Host Cell Type

NSCLC; CHO-K1; HEK293

Target Classification

Kinase Cell Lines

Target Research Area

Cancer Research

Related Diseases

Osteoglophonic Dysplasia and Encephalocraniocutaneous Lipomatosis. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway

Gene ID

2260

UniProt ID

P11362

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Fibroblast growth factor receptor 1 (FGFR1) is a receptor tyrosine kinase whose ligands are certain members of the fibroblast growth factor family. It is also referred to as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331. It has been demonstrated that FGFR1 is linked to clonal eosinophilias and Pfeiffer syndrome. Mice that are genetically modified to be devoid of a functional Fgfr1 gene pass away before reaching 10.5 days of gestation. In terms of the musculoskeletal system and the development and organization of tissues derived from mesoderms, embryos show severe defects. The correct development of the limbs, skull, outer, middle, and inner ear, neural tube, tail, and lower spine appears to depend on the Fgfr1 gene for the truncation of embryonic structures and the synthesis of muscle and bone tissues. The customized FGFR1 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Helen

A very stable FGFR1 cell line, especially as there has not been much variation change during my use. Dec 06 2022

chat Verified Customer

chat Brian

If you are looking for a good value FGFR1 cell line for drug discovery, this is the one. May 08 2022

chat Verified Customer

FAQ

Any questions about our products? Please visit our frequently asked questions page.

Published Data

Fig.1 FGFR1 and FGFR2 protein expression in NSCLC cell lines.

The indicated NSCLC cell lines were subjected to a quantitative RT-PCR experiment for FGFR1 and FGFR2 mRNAs, which was standardized for GAPDH mRNA levels.

Ref: Marek, Lindsay, et al. "Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells." Molecular pharmacology 75.1 (2009): 196-207.

Pubmed: 18849352

DOI: 10.1124/mol.108.049544

Research Highlights

Amplification of FGFR1 is roughly 19%. The amplification of FGFR1 is unaffected by test methodologies, ethnicity, gender, stage, differentiation, or other factors. There is a pattern of correlation between smoking and lymph node metastases and FGFR1 amplification. It's still debatable if FGFR1 amplification affects survival.
Jiang, Tao, et al. "FGFR1 amplification in lung squamous cell carcinoma: a systematic review with meta-analysis." Lung cancer 87.1 (2015): 1-7.
Pubmed: 25433983 DOI: 10.1016/j.lungcan.2014.11.009

Tyrosine kinase inhibitor sensitivity in PDXs is predicted by FGFR1 expression, which is correlated with BGJ398 sensitivity in HNSCC cell lines. These findings validate the use of FGFR1 mRNA or protein expression, as opposed to FGFR1 CNG, as a predictive biomarker for the responsiveness to FGFR inhibitors in a subgroup of HNSCC patients.
Göke, Friederike, et al. "FGFR1 expression levels predict BGJ398 sensitivity of FGFR1-dependent head and neck squamous cell cancers." Clinical cancer research 21.19 (2015): 4356-4364.
Pubmed: 26015511 DOI: 10.1158/1078-0432.CCR-14-3357