ERBB2
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
| Full Name | erb-b2 receptor tyrosine kinase 2 |
| Gene ID | Human: 2064 Mouse: 13866 Rat: 24337 Monkey: 697573 |
| UniProt ID | Human: P04626 Mouse: P70424 Rat: P06494 |
| Alternative Names | NEU; NGL; HER2; TKR1; CD340; HER-2; VSCN2; MLN 19; MLN-19; c-ERB2; c-ERB-2; HER-2/neu; p185(erbB2);receptor tyrosine-protein kinase erbB-2;c-erb B2/neu protein;herstatin;human epidermal growth factor receptor 2;metastatic lymph node gene 19 protein;neuro/glioblastoma derived oncogene homolog;neuroblastoma/glioblastoma derived oncogene homolog;proto-oncogene Neu;proto-oncogene c-ErbB-2;tyrosine kinase-type cell surface receptor HER2;v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2;v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2;v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog |
Product List
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Magic™ Human ERBB2 (V754M) BaF3 Cell Line
[CAT#: S01YF-1222-KX540]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 (V754M) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human ERBB2 (V777, G778insGC) BaF3 Cell Line
[CAT#: S01YF-1222-KX720]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 (V777, G778insGC) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human ERBB2 (T798M) BaF3 Cell Line
[CAT#: S01YF-1222-KX760]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 (T798M) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human ERBB2 (V842I) BaF3 Cell Line
[CAT#: S01YF-1222-KX542]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 (V842I) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human ERBB2 (R678Q) BaF3 Cell Line
[CAT#: S01YF-1222-KX539]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 (R678Q) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human ERBB2 BaF3 Cell Line
[CAT#: S01YF-1222-KX840]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human ERBB2 (P780, Y781insGSP) BaF3 Cell Line
[CAT#: S01YF-1222-KX717]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 (P780, Y781insGSP) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human ERBB2 (L869R, T798I) BaF3 Cell Line
[CAT#: S01YF-1222-KX710]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 (L869R, T798I) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human ERBB2 (L869R) BaF3 Cell Line
[CAT#: S01YF-1222-KX742]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 (L869R) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human ERBB2 (L755S) BaF3 Cell Line
[CAT#: S01YF-1222-KX761]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 (L755S) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human ERBB2 (L755P) BaF3 Cell Line
[CAT#: S01YF-1222-KX772]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 (L755P) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human ERBB2 (G776VC) BaF3 Cell Line
[CAT#: S01YF-1222-KX719]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 (G776VC) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human ERBB2 (G776, V777delinsCVC) BaF3 Cell Line
[CAT#: S01YF-1222-KX541]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 (G776, V777delinsCVC) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human ERBB2 (extracellular domain deletion) BaF3 Cell Line
[CAT#: S01YF-1222-KX839]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 (extracellular domain deletion) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human ERBB2 (C805S) BaF3 Cell Line
[CAT#: S01YF-1222-KX594]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 (C805S) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human ERBB2 (A775, G776insYVMA) BaF3 Cell Line
[CAT#: S01YF-1222-KX813]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 (A775, G776insYVMA) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human ERBB2 (V777L) BaF3 Cell Line
[CAT#: S01YF-1222-KX764]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 (V777L) Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: BaF3 Assay Types: Drug screening and biological assays
Magic™ Human ERBB2 CT26 Cell Line
[CAT#: S01YF-0324-KX56]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: CT26 Assay Types: Functional assay and biological assay
Magic™ Human ERBB2 EMT6 Cell Line
[CAT#: S01YF-0324-KX73]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: EMT6 Assay Types: Functional assay and biological assay
Magic™ Human ERBB2 HEK293 Cell Line
[CAT#: S01YF-1222-KX703]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
Magic™ Human ERBB2 MC-38 Cell Line
[CAT#: S01YF-0324-KX116]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: MC-38 Assay Types: Functional assay and biological assay
mProX™ Human ERBB2 Stable Cell Line
[CAT#: S01YF-1123-KX255]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: MDA-MB-231; MCF7; NIH3T3; CHO-K1; HEK293
Magic™ Human ERBB2 4T1 Cell Line
[CAT#: S01YF-0324-KX18]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: 4T1 Assay Types: Functional assay and biological assay
Magic™ Human ERBB2 T47D Cell Line
[CAT#: S01YF-0123-KX353]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: ERBB2 Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: T47D Assay Types: Drug screening and biological assays
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