mProX™ Human ERBB2 Stable Cell Line
[CAT#: S01YF-1123-KX255]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
ERBB2
Target Family
Kinases/Enzyme Drug Discovery Assays and Products
Target Protein Species
Human
Host Cell Type
MDA-MB-231; MCF7; NIH3T3; CHO-K1; HEK293
Target Classification
Kinase Cell Lines
Target Research Area
CNS Research; Cardiovascular Research; Cancer Research; Reproductive Research
Related Diseases
Visceral Neuropathy, Familial, 2, Autosomal Recessive and Glioma Susceptibility 1. Among its related pathways are Drug resistance in ERBB2 KD mutants and Signaling by ERBB2 KD Mutants
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
The ERBB2 gene encodes the protein known as receptor tyrosine-protein kinase erbB-2, which is typically found in cell membranes. The terms HER2 and CD340 are also commonly used to refer to the human protein. The human epidermal growth factor receptor (HER/EGFR/ERBB) family includes HER2. But unlike other ERBB family members, HER2 does not bind ligand directly. When HER2 concentrations are high, homodimerization occurs, or heterodimerization with another ERBB member resulting in HER2 activation. It has been demonstrated that this oncogene's amplification or overexpression is crucial to the onset and spread of several aggressive forms of breast cancer. For thirty percent of patients with breast cancer, the protein has emerged as a significant diagnostic and therapeutic target in recent years. The customized ERBB2 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Ashley
I have been using the ERBB2 cell line for my research, and it has consistently provided reliable results.
Sep 03 2021
Verified Customer
Thomas
The specificity and reproducibility of this ERBB2 cell line are impressive. I highly recommend it to fellow researchers.
Jun 28 2023
Verified Customer
FAQ
Any questions about our products? Please visit our frequently asked questions page.
