EPHB2
This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants.
| Full Name | EPH receptor B2 |
| Gene ID | Human: 2048 Mouse: 13844 Rat: 313633 Monkey: 718570 |
| UniProt ID | Human: P29323 Mouse: P54763 Rat: B2B9B0 |
| Alternative Names | DRT; EK5; ERK; CAPB; Hek5; PCBC; EPHT3; Tyro5; BDPLT22;ephrin type-B receptor 2;EPH-like kinase 5;developmentally-regulated Eph-related tyrosine kinase;elk-related tyrosine kinase;eph tyrosine kinase 3;protein-tyrosine kinase HEK5;renal carcinoma antigen NY-REN-47;tyrosine-protein kinase TYRO5;tyrosine-protein kinase receptor EPH-3 |
Product List
Loading...
- Product Category:
- Membrane Protein Drug Discovery In Vitro Assays
- Target Protein: EPHB2 Target Family: Kinases/Enzyme Target Protein Species: Human Assay Types: Kinase Assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: EPHB2 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: HGC27; CHO-K1; HEK293
