DDR1
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
| Full Name | discoidin domain receptor tyrosine kinase 1 |
| Gene ID | Human: 780 Mouse: 12305 Rat: 25678 Monkey: 714233 |
| UniProt ID | Human: Q08345 Mouse: Q03146 Rat: Q63474 |
| Alternative Names | CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A;epithelial discoidin domain-containing receptor 1;CD167 antigen-like family member A;PTK3A protein tyrosine kinase 3A;cell adhesion kinase;mammary carcinoma kinase 10;neuroepithelial tyrosine kinase;neurotrophic tyrosine kinase, receptor, type 4;protein-tyrosine kinase RTK-6;tyrosine kinase DDR;tyrosine-protein kinase CAK |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: DDR1 Target Family: Kinases/Enzyme Target Protein Species: Human Protein Tag: Tag-free Host Cell Type: HEK293T Assay Types: Drug screening and biological assays
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: DDR1 Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: LL/2 Assay Types: Functional assay and biological assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: DDR1 Target Family: Kinases/Enzyme Target Protein Species: Human Host Cell Type: MC-38 Assay Types: Functional assay and biological assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: DDR1 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: MCF7; CHO-K1; HEK293
