DCLK2
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.
| Full Name | doublecortin like kinase 2 |
| Gene ID | Human: 166614 Mouse: DCLK2 Rat: 310698 Monkey: 693566 |
| UniProt ID | Human: Q8N568 Mouse: Q6PGN3 Rat: Q5MPA9 |
| Alternative Names | CL2; DCK2; CLIK2; DCDC3; CLICK2; DCDC3B; DCAMKL2; CLICK-II;serine/threonine-protein kinase DCLK2;CaMK-like CREB regulatory kinase 2;doublecortin and CaM kinase-like 2;doublecortin domain-containing protein 3B;doublecortin-like and CAM kinase-like 2 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: DCLK2 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: CHO-K1; HEK293
