DCLK1
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.
| Full Name | doublecortin like kinase 1 |
| Gene ID | Human: 9201 Mouse: 13175 Rat: 83825 Monkey: 722071 |
| UniProt ID | Human: O15075 Mouse: Q9JLM8 Rat: O08875 |
| Alternative Names | CL1; DCLK; CLICK1; DCDC3A; DCAMKL1;serine/threonine-protein kinase DCLK1;doublecortin domain-containing protein 3A;doublecortin-like and CAM kinase-like 1 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: DCLK1 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: CHO-K1; HEK293
