CSK
The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants.
| Full Name | C-terminal Src kinase |
| Gene ID | Human: 1445 Mouse: 12988 Rat: 315707 Monkey: 702868 |
| UniProt ID | Human: P41240 Mouse: P41241 Rat: P32577 |
| Alternative Names | tyrosine-protein kinase CSK;C-Src kinase;CSK, non-receptor tyrosine kinase;c-src tyrosine kinase;protein-tyrosine kinase CYL |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CSK Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: CHO-K1; HEK293
