mProX™ Human CSK Stable Cell Line
[CAT#: S01YF-1123-KX209]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Kinase Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
CSK
Target Family
Kinases/Enzyme Drug Discovery Assays and Products
Target Protein Species
Human
Host Cell Type
CHO-K1; HEK293
Target Classification
Kinase Cell Lines
Target Research Area
Autoimmune Research
Related Diseases
Osteopetrosis and Lupus Erythematosus. Among its related pathways are Signaling downstream of RAS mutants and RAF/MAP kinase cascade.
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
Kinase tyrosine-protein C-terminal is another name for CSK. The CSK gene in humans codes for the enzyme src kinase. Tyrosine residues in the C-terminal end of Src-family kinases (SFKs) are phosphorylated by this enzyme. The control of cell proliferation, differentiation, migration, and immunological response is significantly influenced by this non-receptor tyrosine-protein kinase. By phosphorylating members of the Src family of protein kinases at a conserved C-terminal tail location in Src, CSK inhibits the activity of the Src family of protein kinases. In order to block SFKs, CSK is first drawn to the plasma membrane by attaching itself to transmembrane proteins or adaptor proteins that are in close proximity to the membrane. By phosphorylating and keeping inactive a number of effector molecules, CSK then suppresses signaling through a variety of surface receptors. The customized CSK stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Donna
The CSK cell line has not disappointed. It consistently delivers accurate results, making my work much more impactful.
May 08 2023
Verified Customer
Christopher
The protocol of CSK cell line was straightforward, and the results were consistent.
Apr 21 2020
Verified Customer
FAQ
Any questions about our products? Please visit our frequently asked questions page.
