CHEK1
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.
| Full Name | checkpoint kinase 1 |
| Gene ID | Human: 1111 Mouse: 12649 Rat: 140583 Monkey: 713358 |
| UniProt ID | Human: O14757 Mouse: O35280 Rat: Q91ZN7 |
| Alternative Names | CHK1;serine/threonine-protein kinase Chk1;CHK1 checkpoint homolog;Checkpoint, S. pombe, homolog of, 1;Chk1-S;cell cycle checkpoint kinase |
Product List
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mProX™ Human CHEK1 Stable Cell Line
[CAT#: S01YF-1123-KX193]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: CHEK1 Target Family: Kinases/Enzyme Drug Discovery Assays and Products Target Protein Species: Human Host Cell Type: HCC; CHO-K1; HEK293
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